MLKL anticorps (pSer358)

N° du produit ABIN7212282

Détail du produit anti-MLKL anticorps

Antigène: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Épitope: pSer358

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MLKL est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Fonction: phospho-MLKL (S358) Mouse Monoclonal Antibody (6F8)

Specificité: Phospho-MLKL (S358) protein detects endogenous levels of MLKL.

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen

Immunogène: Synthetic Peptide of phospho-MLKL (S358)

Clone: 6F8

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:200).

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur MLKL

Antigène: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Autre désignation: MLKL (MLKL Produits)

Synonymes: anticorps MLKL, anticorps 9130019I15Rik, anticorps mixed lineage kinase domain like pseudokinase, anticorps mixed lineage kinase domain-like, anticorps MLKL, anticorps mlkl, anticorps Mlkl

Sujet: Mouse Anti-phospho-MLKL (S358) Mouse Monoclonal Antibody (6F8),MLKL,MLKL (mixed lineage kinase domain like) belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of MLKL inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for MLKL.,MLKL

Poids moléculaire: observerd band 54kDa

ID gène: 197259

UniProt: Q8NB16