ARIH1 anticorps (C-Term)

N° du produit ABIN7265672

Détail du produit anti-ARIH1 anticorps

Antigène: ARIH1 (Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARIH1 est non-conjugé

Application: Western Blotting (WB)

Fonction: ARIH1 Rabbit pAb

Séquence: ARDAQERSRA ALQRYLFYCN RYMNHMQSLR FEHKLYAQVK QKMEEMQQHN MSWIEVQFLK KAVDVLCQCR ATLMYTYVFA FYLKKNNQSI IFENNQADLE NATEVLSGYL ERDISQDSLQ DIKQKVQDKY RYCESRRRVL LQHVHEGYEK DLWEYIED

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human ARIH1 (NP_005735.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ARIH1

Antigène: ARIH1 (Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1))

Autre désignation: ARIH1 (ARIH1 Produits)

Synonymes: anticorps ARIH1, anticorps ARI-1, anticorps ari, anticorps ariadne, anticorps hari, anticorps hhari, anticorps ubch7bp, anticorps ARI, anticorps HARI, anticorps HHARI, anticorps UBCH7BP, anticorps AU021774, anticorps Ari, anticorps Ari1, anticorps Hari, anticorps Hhari, anticorps Ubch7bp, anticorps Uip77, anticorps wu:fa18d01, anticorps zgc:66364, anticorps ariadne RBR E3 ubiquitin protein ligase 1, anticorps ariadne RBR E3 ubiquitin protein ligase 1 L homeolog, anticorps ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila), anticorps Arih1, anticorps ARIH1, anticorps arih1, anticorps arih1.L

Sujet: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes. Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear. According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report EIF4E2 ubiquitination leads to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology.,ARIH1,ARI,HARI,HHARI,UBCH7BP,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,Endocrine & Metabolism,Amino acid metabolism,ARIH1

ID gène: 25820

UniProt: Q9Y4X5