CIC anticorps (AA 1379-1608)
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- Antigène Voir toutes CIC Anticorps
- CIC (Capicua Homolog (CIC))
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Épitope
- AA 1379-1608
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CIC est non-conjugé
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Application
- Western Blotting (WB)
- Fonction
- CIC Rabbit pAb
- Séquence
- LATSPRAILG SYRKKRKNST DLDSAPEDPT SPKRKMRRRS SCSSEPNTPK SAKCEGDIFT FDRTGTEAED VLGELEYDKV PYSSLRRTLD QRRALVMQLF QDHGFFPSAQ ATAAFQARYA DIFPSKVCLQ LKIREVRQKI MQAATPTEQP PGAEAPLPVP PPTGTAAAPA PTPSPAGGPD PTSPSSDSGT AQAAPPLPPP PESGPGQPGW EGAPQPSPPP PGPSTAATGR
- Réactivité croisée
- Humain, Souris
- Attributs du produit
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein containing a sequence corresponding to amino acids 1379-1608 of human CIC (NP_055940.3).
- Isotype
- IgG
- Top Product
- Discover our top product CIC Anticorps primaire
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- Indications d'application
- WB,1:200 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- CIC (Capicua Homolog (CIC))
- Autre désignation
- CIC (CIC Produits)
- Synonymes
- anticorps wu:fb93c01, anticorps CIC, anticorps 1200010B10Rik, anticorps mKIAA0306, anticorps capicua transcriptional repressor b, anticorps capicua transcriptional repressor, anticorps cicb, anticorps CIC, anticorps Cic
- Sujet
- The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.,CIC,Epigenetics & Nuclear Signaling,Neuroscience,Neurodegenerative Diseases,CIC
- Poids moléculaire
- 163kDa
- ID gène
- 23152
- UniProt
- Q96RK0
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