Human Immunodeficiency Virus Type I Enhancer Binding Protein 3 (HIVEP3) anticorps

N° du produit ABIN7267792

Détail du produit

Antigène: Human Immunodeficiency Virus Type I Enhancer Binding Protein 3 (HIVEP3)

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Fonction: Hivep3 Rabbit pAb

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant protein of Mouse Hivep3.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détail du antigène

Antigène: Human Immunodeficiency Virus Type I Enhancer Binding Protein 3 (HIVEP3)

Autre désignation: Hivep3 (HIVEP3 Produits)

Synonymes: anticorps 2900056N03Rik, anticorps A130075N07, anticorps AI848000, anticorps E030045D18Rik, anticorps KBP-1, anticorps KBP1, anticorps Krc, anticorps Rc, anticorps Schnurri-3, anticorps Shn3, anticorps Zas3, anticorps KRC, anticorps SHN3, anticorps ZAS3, anticorps ZNF40C, anticorps human immunodeficiency virus type I enhancer binding protein 3, anticorps human immunodeficiency virus type I enhancer binding protein 3 L homeolog, anticorps transcription factor HIVEP3, anticorps HIVEP3, anticorps hivep3.L, anticorps LOC100409919, anticorps hivep3, anticorps Hivep3

Sujet: Plays a role of transcription factor, binds to recognition signal sequences (Rss heptamer for somatic recombination of immunoglobulin and T-cell receptor gene segments, Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation, Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus, through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.,Kr, Rc, Sh, Krc, KBP1, Shn3, Zas3, KBP-1, Schnu, AI848000, A130075N07, Schnurri-3, 2900056N03Rik, E030045D18Rik,Hivep3

Poids moléculaire: 253kDa

ID gène: 16656

UniProt: A2A884