RAF1 anticorps (pSer621)

N° du produit ABIN7271267

L’anticorps Lapin Monoclonal anti-RAF1 a été validé pour WB. Il convient pour détecter RAF1 dans des échantillons de Humain.

Aperçu rapide pour RAF1 anticorps (pSer621) (ABIN7271267)

Antigène: RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp RAF1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RAF1 anticorps

Épitope: pSer621

Fonction: Phospho-Raf1-S621 Rabbit mAb

Réactivité croisée: Humain, Rat

Attributs du produit: Phosphorylated Antibodies

Purification: Affinity purification

Immunogène: A phospho specific peptide corresponding to residues surrounding S621 of human Phospho-Raf1-S621

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur RAF1

Antigène: RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))

Autre désignation: RAF1

Sujet: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008],CMD1NN, CRAF, NS5, Raf-1, c-Raf,Apoptosis,Apoptosis_Inhibition of Apoptosis,B Cell Receptor Signaling Pathway,Cancer,Cell Biology & Developmental Biology,Endocrine & Metabolism,ErbB-HER Signaling Pathway,ESC Pluripotency and Differentiation,G protein signaling,G protein signaling_G-Protein-Coupled Receptors Signaling to MAPK/Erk,Growth factors,IL-6 Receptor Signaling Pathway,Immunology & Inflammation,Insulin Receptor Signaling Pathway,Kinase,Kinase_Serine/threonine kinases,MAPK-Erk Signaling Pathway,Mitochondrial metabolism,Mitochondrial metabolism_Mitochondrial markers,Neuroscience,Protein phosphorylation,Signal Transduction,T Cell Receptor Signaling Pathway,RAF1

Poids moléculaire: 74kDa

ID gène: 5894

UniProt: P04049

Pathways: Signalisation MAPK, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Stem Cell Maintenance, Hepatitis C, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling, BCR Signaling