CSTF2T anticorps (AA 225-275)

N° du produit ABIN7452301

Détail du produit anti-CSTF2T anticorps

Antigène: CSTF2T (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa, tau Variant (CSTF2T))

Épitope: AA 225-275

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSTF2T est non-conjugé

Application: Immunoprecipitation (IP)

Fonction: Rabbit anti-CSTF2T/TauCSTF64 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 225 and 275

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-CSTF2T/TauCSTF64 antibody A301-487A.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur CSTF2T

Antigène: CSTF2T (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa, tau Variant (CSTF2T))

Autre désignation: CSTF2T/TauCSTF64 (CSTF2T Produits)

Synonymes: anticorps 64kDa, anticorps C77975, anticorps tCstF-64, anticorps tauCstF-64, anticorps CstF-64T, anticorps cleavage stimulation factor, 3' pre-RNA subunit 2, tau, anticorps cleavage stimulation factor subunit 2 tau variant, anticorps cleavage stimulation factor subunit 2, tau variant, anticorps Cstf2t, anticorps CSTF2T

Sujet: Background: CSTF2T, also known as tauCSTF-64, is a paralog of CstF-64, a component of the cleavage stimulation factor (CstF) that processes 3'-end formation and polyadenylation of mRNAs. The human CSTF2T/TauCSTF64 gene is located at 10q22-23, a site associated with neurological problems and male infertility. CSTF2T is expressed in all tissues and throughout meiosis in male germ cells. CstF-64 is also expressed ubiquitously, however because it is located on the X chromosome, its expression is temporarily silenced in germ cells by meiotic sex chromosome inactivation. During this inactivation, it is hypothesized that CSTF2T/TauCSTF64 can compensate for the loss of CstfF-64 expression. Recently, targeted disruption of CSTF2T/TauCSTF64 in mice has been shown to cause aberrant spermatogenesis and infertility providing more evidence for its importance in spermatogenesis.

ID gène: 23283

NCBI Accession: NP_056050

UniProt: Q9H0L4