ERBB4 anticorps (AA 1100-1150)

N° du produit ABIN7452483

Cet anticorps anti-ERBB4 est un anticorps Lapin Polyclonal détectant ERBB4 dans IP. Adapté pour Humain.

Aperçu rapide pour ERBB4 anticorps (AA 1100-1150) (ABIN7452483)

Antigène: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERBB4 est non-conjugé

Application: Immunoprecipitation (IP)

Détail du produit anti-ERBB4 anticorps

Épitope: AA 1100-1150

Fonction: Rabbit anti-ErbB4 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 1100 and 1150

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: Not recommended.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur ERBB4

Antigène: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Autre désignation: ErbB4

Sujet: Background: ErbB4 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor, EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors homo- or heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ligands preferred by ErbB4 include neuregulins (NRG-2 and NRG-3), heparin-binding EGF-like growth factor, and betacellulin, and epiregulin. ErbB4 appears to be important to mammary gland development and lactation, however its role in breast cancer has not been unequivocally determined.

ID gène: 2066

NCBI Accession: NP_005226

UniProt: Q15303

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway