JMY anticorps (AA 800-850)

N° du produit ABIN7452890

Détail du produit anti-JMY anticorps

Antigène: JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))

Épitope: AA 800-850

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JMY est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit anti-JMY Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 800 and 850

Isotype: IgG

Information d'application

Indications d'application:

IP: Not recommended. Use rabbit anti-JMY antibody A302-572A.

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur JMY

Antigène: JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))

Autre désignation: JMY (JMY Produits)

Synonymes: anticorps WHDC1L3, anticorps junction mediating and regulatory protein, p53 cofactor, anticorps junction-mediating and regulatory protein, anticorps JMY, anticorps jmy, anticorps Jmy

Sujet: Background: Junction-mediating and -regulatory protein (JMY) acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In the nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300 and increases p53/TP53-dependent transcription and apoptosis suggesting an important role in p53/TP53 stress response such as DNA damage. In the cytoplasm, JMY acts as a nucleation-promoting factor for both branched and un-branched actin filaments. It activates the Arp2/3 complex to induce branched actin filament networks and also catalyzes actin polymerization in the absence of Arp2/3, creating un-branched filaments [taken from the Universal Protein Resource (UniProt) Q8N9B5].

ID gène: 133746

NCBI Accession: NP_689618

UniProt: Q8N9B5

Pathways: Regulation of Actin Filament Polymerization