MIB2 anticorps (AA 925-975)

N° du produit ABIN7452954

Détail du produit anti-MIB2 anticorps

Antigène: MIB2 (E3 ubiquitin-protein ligase MIB2 (MIB2))

Épitope: AA 925-975

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MIB2 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit anti-MIB2/Skeletrophin Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 925 and 975

Isotype: IgG

Information d'application

Indications d'application:

IP: Not recommended

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur MIB2

Antigène: MIB2 (E3 ubiquitin-protein ligase MIB2 (MIB2))

Autre désignation: MIB2/Skeletrophin (MIB2 Produits)

Synonymes: anticorps ZZANK1, anticorps ZZZ5, anticorps 2210008I11Rik, anticorps Zzank1, anticorps skd, anticorps mib2, anticorps mindbomb E3 ubiquitin protein ligase 2, anticorps mindbomb E3 ubiquitin protein ligase 2 S homeolog, anticorps MIB2, anticorps Mib2, anticorps mib2, anticorps mib2.S

Sujet: Background: MIB2/Skeletrophin is an actin-binding protein that bears two MIB/HERC2 domains, a ZZ-type zinc-finger domain, nine ankyrin repeats, and two RING-finger domains. The C-terminal RING domain has been found to have E3 ubiquitin ligase activity that mediates ubiquitination of the intracellular regions of the Notch receptor and its ligands to regulate Notch signaling. MIB2/Skeletrophin appears to be important to muscle development and may function as a suppressor of melanoma invasion.

ID gène: 142678

NCBI Accession: NP_543151

UniProt: Q96AX9

Pathways: Signalisation Notch