SARM1 anticorps (C-Term)

N° du produit ABIN7466589

Cet anticorps Lapin Polyclonal détecte spécifiquement SARM1 dans WB, ICC et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour SARM1 anticorps (C-Term) (ABIN7466589)

Antigène: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SARM1 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Classe de qualité: KO Validated

Détail du produit anti-SARM1 anticorps

Épitope: C-Term

Specificité: Knockdown/Knockout validation was supported by references (PMID:36055989)

Réactivité croisée: Drosophila melanogaster, Humain, Souris

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human SARM1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Validation: KO/KD, Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: 1XPBS pH 7, 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur SARM1

Antigène: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Autre désignation: sterile alpha and TIR motif containing 1

Sujet: Sterile alpha and TIR motif containing 1 , MyD88-5 , SAMD2 , SARM,Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.

Poids moléculaire: 79 kDa

ID gène: 23098

UniProt: Q6SZW1

Pathways: Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades