SARM1 anticorps

N° du produit ABIN7270591

Détail du produit anti-SARM1 anticorps

Antigène: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SARM1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: SARM1 Rabbit pAb

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant protein of human SARM1.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IP,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SARM1

Antigène: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Autre désignation: SARM1 (SARM1 Produits)

Synonymes: anticorps A830091I15Rik, anticorps C78606, anticorps MyD885, anticorps Sarm, anticorps MyD88-5, anticorps SAMD2, anticorps SARM, anticorps sterile alpha and TIR motif containing 1, anticorps sterile alpha and HEAT/Armadillo motif containing 1, anticorps SARM1, anticorps Sarm1, anticorps sarm1

Sujet: NAD(+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+ metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+ into ADP-D-ribose (ADPR, cyclic ADPR (cADPR and nicotinamide, NAD(+ cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+, but not other NAD(+-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.,SARM, HsTIR, SAMD2, hSARM1, MyD88-5,SARM1

Poids moléculaire: 79kDa

ID gène: 23098

UniProt: Q6SZW1

Pathways: Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades