ATR anticorps (AA 710-1100)

N° du produit ABIN7467985

L’anticorps Souris Monoclonal anti-ATR a été validé pour WB, IP, ICC, IF et Func. Il convient pour détecter ATR dans des échantillons de Humain.

Aperçu rapide pour ATR anticorps (AA 710-1100) (ABIN7467985)

Antigène: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATR est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Functional Studies (Func)

Clone: 2B5

Détail du produit anti-ATR anticorps

Épitope: AA 710-1100

Réactivité croisée: Humain, Souris

Purification: Protein G purified

Immunogène: Recombinant fragment, corresponding to amino acids 710-1100 of Human ATR.

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Raji , Raji nuclear extract Validation: Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, No Preservative

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur ATR

Antigène: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Autre désignation: ATR serine/threonine kinase

Sujet:

Synonyms: ATR serine/threonine kinase , FCTCS , FRP1 , MEC1 , SCKL , SCKL1

Background: The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]

Poids moléculaire: 301 kDa

ID gène: 545

UniProt: Q13535

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus