Retinoblastoma Binding Protein 8 anticorps

N° du produit ABIN7468880

Cet anticorps anti-Retinoblastoma Binding Protein 8 est un anticorps Souris Monoclonal détectant Retinoblastoma Binding Protein 8 dans WB, IP, ICC, IF, PLA et ChIP. Adapté pour Humain.

Aperçu rapide pour Retinoblastoma Binding Protein 8 anticorps (ABIN7468880)

Antigène: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Retinoblastoma Binding Protein 8 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Proximity Ligation Assay (PLA), Chromatin Immunoprecipitation (ChIP)

Classe de qualité: KO Validated

Clone: 1-90E-09

Détail du produit anti-Retinoblastoma Binding Protein 8 anticorps

Réactivité croisée: Humain, Souris

Purification: Protein G purified

Immunogène: Human CtIP

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500-1:1000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Validation: KO/KD, Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, No preservative

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur Retinoblastoma Binding Protein 8

Antigène: Retinoblastoma Binding Protein 8 (RBBP8)

Autre désignation: RB binding protein 8, endonuclease

Sujet:

Synonyms: RB binding protein 8, endonuclease , COM1 , CTIP , JWDS , RIM , SAE2 , SCKL2

Background: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

Poids moléculaire: 102 kDa

ID gène: 5932

UniProt: Q99708

Pathways: Cycle Cellulaire, Réparation de l'ADN