KCNQ1 anticorps (AA 501-600)

N° du produit ABIN721015

Détail du produit anti-KCNQ1 anticorps

Antigène: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Épitope: AA 501-600

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNQ1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog,Cow,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human KCNQ-1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-KCNQ1 (ABIN721015)

Trotta, Ferraro, Messina, Panarese, Gulotta, Nicoletti, DAmico, Pieretti: "Telmisartan cardioprotects from the ischaemic/hypoxic damage through a miR-1-dependent pathway." dans: Journal of cellular and molecular medicine, Vol. 23, Issue 10, pp. 6635-6645, (2020) (PubMed).

Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: "Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications." dans: Basic research in cardiology, Vol. 109, Issue 5, pp. 427, (2014) (PubMed).

Détails sur KCNQ1

Antigène: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Autre désignation: KCNQ1 (KCNQ1 Produits)

Synonymes: anticorps ATFB1, anticorps ATFB3, anticorps JLNS1, anticorps KCNA8, anticorps KCNA9, anticorps KVLQT1, anticorps Kv1.9, anticorps Kv7.1, anticorps LQT, anticorps LQT1, anticorps RWS, anticorps SQT2, anticorps WRS, anticorps CG12215, anticorps CG12915, anticorps CG33135, anticorps DKCNQ, anticorps Dmel\\CG33135, anticorps dKCNQ, anticorps kcnq1, anticorps KCNQ1, anticorps kqt-3, anticorps kv7.1, anticorps Kvlqt1, anticorps KvLQT-1, anticorps kcnq1-A, anticorps xkvlqt1, anticorps zgc:158384, anticorps AW559127, anticorps Kcna9, anticorps KvLQT1, anticorps potassium voltage-gated channel subfamily Q member 1, anticorps KCNQ potassium channel, anticorps potassium voltage-gated channel, KQT-like subfamily, member 1, anticorps potassium channel, voltage gated KQT-like subfamily Q, member 1, anticorps voltage gated potassium channel subunit, anticorps potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog, anticorps potassium voltage-gated channel, subfamily Q, member 1, anticorps KCNQ1, anticorps KCNQ, anticorps kcnq1, anticorps Kcnq1, anticorps kcnq1.L

Sujet:

Synonyms: LQT, RWS, WRS, LQT1, SQT2, ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, Kv1.9, Kv7.1, KVLQT1, Potassium voltage-gated channel subfamily KQT member 1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv7.1, KCNQ1

Background: Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.

ID gène: 3784

UniProt: P51787

Pathways: Negative Regulation of Hormone Secretion, Sensory Perception of Sound