Caspase 9 anticorps (AA 271-314)

N° du produit ABIN724175

Détail du produit anti-Caspase 9 anticorps

Antigène: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Épitope: AA 271-314

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 9 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Caspase-9 subunit p35

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Caspase 9 (ABIN724175)

Gao, Liu, Li, Wu, Peng, Jing: "Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer." dans: American journal of translational research, Vol. 8, Issue 2, pp. 1115-32, (2016) (PubMed).

Yin, Zhang, Cao, Duan, Shi, Zhao, Camara, Shen, Wang: "Bmi1 inhibition enhances the sensitivity of pancreatic cancer cells to gemcitabine." dans: Oncotarget, Vol. 7, Issue 24, pp. 37192-37204, (2016) (PubMed).

Shan, Fan: "Cytotoxicity of carteolol to human corneal epithelial cells by inducing apoptosis via triggering the Bcl-2 family protein-mediated mitochondrial pro-apoptotic pathway." dans: Toxicology in vitro : an international journal published in association with BIBRA, Vol. 35, pp. 36-42, (2016) (PubMed).

Pang, Fan: "Cytotoxic effect and possible mechanisms of Tetracaine on human corneal epithelial cells in vitro." dans: International journal of ophthalmology, Vol. 9, Issue 4, pp. 497-504, (2016) (PubMed).

Détails sur Caspase 9

Antigène: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Autre désignation: Caspase-9 (CASP9 Produits)

Synonymes: anticorps CASP9, anticorps AI115399, anticorps APAF-3, anticorps AW493809, anticorps CASP-9, anticorps Caspase-9, anticorps ICE-LAP6, anticorps Mch6, anticorps Apaf3, anticorps Casp-9-CTD, anticorps Casp9_v1, anticorps Ice-Lap6, anticorps APAF3, anticorps MCH6, anticorps PPP1R56, anticorps caspase 9, anticorps CASP9, anticorps Casp9

Sujet:

Synonyms: MCH6, APAF3, APAF-3, PPP1R56, ICE-LAP6, Caspase-9, CASP-9, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, ICE-like apoptotic protease 6, CASP9

Background: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

ID gène: 842

UniProt: P55211

Pathways: Signalisation MAPK, Signalisation RTK, Apoptose, Caspase Cascade in Apoptosis, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity