BAX anticorps (AA 84-175)

N° du produit ABIN725390

L’anticorps Lapin Polyclonal anti-BAX a été validé pour WB, ELISA, FACS, IP, IHC (p), IF (cc), IF (p) et IHC (fro). Il convient pour détecter BAX dans des échantillons de Humain, Souris, Rat, Porc, Boeuf (Vache), Lapin, Poulet et Poisson zèbre (Danio rerio). Il y a 34+ publications disponibles.

Aperçu rapide pour BAX anticorps (AA 84-175) (ABIN725390)

Antigène: BAX (BCL2-Associated X Protein (BAX))

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Lapin, Poulet, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAX est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-BAX anticorps

Épitope: AA 84-175

Réactivité croisée: Poulet, Boeuf (Vache), Humain, Souris, Porc, Lapin, Rat, Poisson zèbre (Danio rerio)

Homologie: Dog,Cow,Sheep

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Bax

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
IP(1-2 μg)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-BAX (ABIN725390)

Zeng, Yi, Huang, An, Wang: "Long-term arsenite exposure induces testicular toxicity by redox imbalance, G2/M cell arrest and apoptosis in mice." dans: Toxicology, Vol. 411, pp. 122-132, (2019) (PubMed).

Si, Zhou, Zhao, Xie, Gan, Zhang, Wang, Zhou, Ren, Zhang: "Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity." dans: Toxicology, Vol. 411, pp. 143-153, (2019) (PubMed).

Liu, Li, Yang, Niu, Zhao, Zhao, Wang: "Valproic acid attenuates inflammation of optic nerve and apoptosis of retinal ganglion cells in a rat model of optic neuritis." dans: Biomedicine & pharmacotherapy, Vol. 96, pp. 1363-1370, (2018) (PubMed).

Abdel-Hamid, El-Azab, Moustafa: "Macrolide antibiotics differentially influence human HepG2 cytotoxicity and modulate intrinsic/extrinsic apoptotic pathways in rat hepatocellular carcinoma model." dans: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 390, Issue 4, pp. 379-395, (2017) (PubMed).

Rahman, Ukiana, Uson-Lopez, Sikder, Saito, Kurasaki: "Cytotoxic effects of cadmium and zinc co-exposure in PC12 cells and the underlying mechanism." dans: Chemico-biological interactions, Vol. 269, pp. 41-49, (2017) (PubMed).

Liu, Su, Hao, Chen, Liu, Liao, Li: "Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice." dans: International journal of molecular sciences, Vol. 17, Issue 1, (2016) (PubMed).

Aksu, Özkaraca, Kandemir, Ömür, Eldutar, Küçükler, Çomaklı: "Mitigation of paracetamol-induced reproductive damage by chrysin in male rats via reducing oxidative stress." dans: Andrologia, Vol. 48, Issue 10, pp. 1145-1154, (2016) (PubMed).

Daverey, Agrawal: "Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes." dans: Neuroscience, Vol. 333, pp. 92-103, (2016) (PubMed).

Yang, Lu, Guo: "Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis." dans: Molecular medicine reports, Vol. 14, Issue 5, pp. 4075-4082, (2016) (PubMed).

She, Zhao, Zhu, Han, Xia, Bai, Zhang, Li: "Aluminum Trichloride Disorders Bile Acid Secretion and Induces Hepatocyte Apoptosis in Rats." dans: Cell biochemistry and biophysics, (2015) (PubMed).

Huang, Zou, Shi, Zhang, Peng, Zhang, Gao, Wang, Zhang: "Electroacupuncture stimulates remodeling of extracellular matrix by inhibiting apoptosis in a rabbit model of disc degeneration." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 386012, (2015) (PubMed).

Li, Zhang, Liu, Ren, Song, Rao, Takahashi, Zhou, Li, Chen: "Deficits of learning and memory in Hemojuvelin knockout mice." dans: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, (2015) (PubMed).

Park, Kim, Choi, Heo, Park: "New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro." dans: Cellular signalling, Vol. 27, Issue 9, pp. 1831-9, (2015) (PubMed).

He, Han, Hu, Zhang, Hua, Peng: "Canonical Wnt signaling pathway contributes to the proliferation and survival in porcine pancreatic stem cells (PSCs)." dans: Cell and tissue research, Vol. 362, Issue 2, pp. 379-88, (2015) (PubMed).

Han, Ji, Chen, Yin, Xu, Li, Chen, Zhu, Peng: "Protective effects of tao-Hong-si-wu decoction on memory impairment and hippocampal damage in animal model of vascular dementia." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 195835, (2015) (PubMed).

Mori, Akita, Tanida, Ishida, Toda, Inoue, Yashiro, Sawada, Hirakawa, Nakada et al.: "MUC1 protein induces urokinase-type plasminogen activator (uPA) by forming a complex with NF-κB p65 transcription factor and binding to the uPA promoter, leading to enhanced invasiveness of cancer ..." dans: The Journal of biological chemistry, Vol. 289, Issue 51, pp. 35193-204, (2015) (PubMed).

Peng, Fu, Guo, Zhang, Di, Jiang, Li: "Effects and Mechanism of Baicalin on Apoptosis of Cervical Cancer HeLa Cells I n -v itro." dans: Iranian journal of pharmaceutical research : IJPR, Vol. 14, Issue 1, pp. 251-61, (2015) (PubMed).

He, Song, Liu, Chen, Hua: "Rapamycin inhibits acrolein-induced apoptosis by alleviating ROS-driven mitochondrial dysfunction in male germ cells." dans: Cell proliferation, Vol. 47, Issue 2, pp. 161-71, (2014) (PubMed).

Ye, Li, Li, Yang, Niu, Wang: "Anti-tumor activity and relative mechanism of ethanolic extract of Marsdenia tenacissima (Asclepiadaceae) against human hematologic neoplasm in vitro and in vivo." dans: Journal of ethnopharmacology, Vol. 153, Issue 1, pp. 258-67, (2014) (PubMed).

Lin, Wang, Wang, Fang, Zhang, Yang, Guo, Lin, Zhang, Wang: "Lithocarpus polystachyus REHD leaf aqueous extract inhibits human breast cancer growth in vitro and in vivo." dans: Nutrition and cancer, Vol. 66, Issue 4, pp. 613-24, (2014) (PubMed).

Détails sur BAX

Antigène: BAX (BCL2-Associated X Protein (BAX))

Autre désignation: Bax

Sujet:

Synonyms: BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX

Background: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

ID gène: 581

UniProt: Q07812

Pathways: Signalisation p53, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response