Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 470-520) anticorps

Détails pour le produit réf. ABIN725930
Antigène
  • 11
  • CG1725
  • CG1730
  • CPD
  • DLG
  • DLG-A
  • Discs-large
  • Dlg
  • Dlg-A
  • Dlg1
  • DlgA
  • Dmel\\CG1725
  • Drodlg
  • PSD95
  • SAP97
  • anon-EST:Posey93
  • anon-WO03040301.258
  • anon-WO03040301.260
  • anon-WO03040301.268
  • d. lg.-1
  • dlg
  • dlg-1
  • dlg-A
  • dlgA
  • dlgS97
  • l(1)10Bf
  • l(1)G0276
  • l(1)G0342
  • l(1)G0456
  • l(1)G19
  • l(1)L11
  • l(1)bwn
  • l(1)d.lg-1
  • l(1)d.lg.-1
  • l(1)discs large
  • l(1)dlg
  • l(1)dlg-1
  • l(1)dlg1
  • l(1)l.pr.-2
  • l(1)lpr-2
  • misb
  • dlgh4
  • psd95
  • sap90
  • sap-90
  • LLGL1
  • Dlgh4
  • PSD-95
  • SAP90
  • SAP90A
  • Sap90
  • SAP-90
  • DLG4
  • discs large 1
  • discs, large homolog 4
  • discs large MAGUK scaffold protein 4
  • discs, large homolog 4b (Drosophila)
  • discs, large homolog 4 (Drosophila)
  • dlg1
  • dlg4
  • DLG4
  • dlg4b
  • Dlg4
Épitope
AA 470-520
16
16
15
14
14
10
8
8
6
5
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
289
288
275
144
5
5
5
4
3
3
2
2
1
1
1
1
1
Hôte
Lapin
163
155
15
1
Clonalité
Polyclonal
Conjugué
Inconjugué
15
10
8
8
8
8
8
8
8
7
7
7
6
6
6
6
6
6
6
6
6
6
4
3
3
3
3
3
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
254
164
98
76
48
41
38
32
23
19
7
6
3
2
1
1
Options
Immunogène KLH conjugated synthetic peptide derived from human PSD95
Isotype IgG
Purification Purified by Protein A.
Antigène
Autre désignation Post-Synaptic Density Protein 95 (DLG4 Antibody Extrait)
Sujet

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).

Subcellular location: Cell membrane

Synonyms: PSD95, SAP9, SAP-9, Disks large homolog 4, Postsynaptic density protein 95, PSD-95, Synapse-associated protein 9, DLG4

ID gène 1742
UniProt P78352
Pathways Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months
Images (Fournisseur)
Immunohistochemistry (IHC) image for anti-Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 470-520) antibody (ABIN725930) Formalin-fixed and paraffin embedded: rat brain tissue labeled with Anti-PSD-95 Polyc...
Produit citée dans: Ku, Li, Gao, Zhang, Yan, Ji, Li, Sang: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." dans: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, 2018 (PubMed). Méthode utilisée: Western Blotting (WB) Détails: Sample: brain

Luo, Guo, Fan, Lu, Chen, Wang, Shao, Wu, Xu, Lü: "Niche astrocytes promote the survival, proliferation and neuronal differentiation of co-transplanted neural stem cells following ischemic stroke in rats." dans: Experimental and therapeutic medicine, Vol. 13, Issue 2, pp. 645-650, 2017 (PubMed). Méthode utilisée: Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (Échantillon (espèces): Rat (Rattus)). Détails: Sample: Corona

Li, Wei, Bai, Li, Huang, Lin, Hou, Deng, Zhou, Zhang, Chen: "MicroRNA-574 is involved in cognitive impairment in 5-month-old APP/PS1 mice through regulation of neuritin." dans: Brain research, Vol. 1627, pp. 177-88, 2015 (PubMed). Méthode utilisée: Western Blotting (WB) (Échantillon (espèces): Mouse (Murine)). Détails: Sample: Brain

Zhao, Li, Wei, Savage, Zhou, Ma: "Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring." dans: Neurobiology of disease, Vol. 68, pp. 145-55, 2014 (PubMed). Méthode utilisée: Western Blotting (WB) (Échantillon (espèces): Rat (Rattus)). Détails: Sample: Brain

Wang, Niu, Zhu, Han, Luo, Zhou, Wang: "Changes in memory and synaptic plasticity induced in male rats after maternal exposure to bisphenol A." dans: Toxicology, Vol. 322, pp. 51-60, 2014 (PubMed). Méthode utilisée: Western Blotting (WB) (Échantillon (espèces): Rat (Rattus)). Détails: Sample: Brain

Zhang, Zheng, Wan, Shao, Liu, Zhang, Zhang: "The potential use of H102 peptide-loaded dual-functional nanoparticles in the treatment of Alzheimer's disease." dans: Journal of controlled release : official journal of the Controlled Release Society, Vol. 192, pp. 317-24, 2014 (PubMed). Méthode utilisée: Western Blotting (WB) (Échantillon (espèces): Mouse (Murine)). Détails: Sample: Brain

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