BRAF anticorps

N° du produit ABIN7598850

Cet anticorps Lapin Monoclonal détecte spécifiquement BRAF dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour BRAF anticorps (ABIN7598850)

Antigène: BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp BRAF est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: G11-G

Détail du produit anti-BRAF anticorps

Fonction: Anti-Braf

Specificité: Braf

Immunogène: Peptide derived from human B-raf surrounding the Val-600 residue (corresponds to Val 637 of mouse or rat B-raf)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 20 mM Tris-HCI, pH 8.0, Stabilizer: 20 mg/mL BSA, Preservative: 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: +2 °C to +8 °C

Détails sur BRAF

Antigène: BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))

Autre désignation: Braf

Sujet: B-raf proto-oncogene belongs to a large group of serine/threonine kinases of RAF family, involved in the transduction of mitogenic signals from the cell membrane to the nucleus. This protein kinase is frequently mutated in thyroid cancer and human melanomas, less frequently in other types of malignant tissues, including colorectal cancers, lung cancers and gliomas. Ninety percent of B-raf mutations are represented by B-raf V600-E mutation, presented by up to 500-fold increased activation in MEK/ERK signaling in tumor cells.

UniProt: P15056

Pathways: Signalisation MAPK, Signalisation RTK, Neurotrophin Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Hepatitis C, Autophagy