FGFR1 anticorps

N° du produit ABIN726605

L’anticorps Lapin Polyclonal anti-FGFR1 a été validé pour WB, IF (p) et IHC (p). Il convient pour détecter FGFR1 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Poulet et Chien.

Aperçu rapide pour FGFR1 anticorps (ABIN726605)

Antigène: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Poulet, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGFR1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-FGFR1 anticorps

Réactivité croisée: Poulet, Boeuf (Vache), Chien, Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human BFGFR

Isotype: IgG

Information d'application

Indications d'application: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur FGFR1

Antigène: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Autre désignation: FGFR1

Sujet:

Synonyms: bFGF R, BFGFR, C FGR, CD 331, CD331, CD331 antigen, CEK, FGFBR, FGFR 1, FGF Receptor 1, Fibroblast growth factor receptor 1, FLG, FLG protein, FLJ14326, FLT 2, FLT2, Fms like tyrosine kinase 2, Fms related tyrosine kinase 2, Fms related tyrosine kinase 2 Pfefer syndrome, H2, H3, H4, H5, HBGFR, Heparin binding growth factor receptor, Hydroxyaryl protein kinase, KAL 2, KAL2, MFR, N SAM, N sam tyrosine kinase, Protein tyrosine kinase, Tyrosylprotein kinase, Basic fibroblast growth factor receptor 1.

Background: Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.

Poids moléculaire: 90kDa

ID gène: 2260

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins