ERBB4 anticorps (AA 1116-1269)

N° du produit ABIN7661754

Cet anticorps anti-ERBB4 est un anticorps Souris Monoclonal détectant ERBB4 dans IF et FACS. Adapté pour Humain et Souris.

Aperçu rapide pour ERBB4 anticorps (AA 1116-1269) (ABIN7661754)

Antigène: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ERBB4 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: HFR-1

Détail du produit anti-ERBB4 anticorps

Épitope: AA 1116-1269

Fonction: HER-4 / ERBB4(HFR-1)

Attributs du produit: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant human ERBB4 (HER4) protein fragment (around aa 1116-1269)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Predicted to react with Rat, Chicken, Flow cytometry: 1-2 μg/million cells, Immunofluorescence: 1-2 μg/mL, Optimal dilution for a specific application should be determined.

Commentaires:

Positive Control: Breast, brain, heart or kidney. MCF-7 cells.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, no BSA, no azide

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Store at -20 °C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur ERBB4

Antigène: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Autre désignation: ERBB4

Sujet:

Synonyms: Avian erythroblastic leukemia viral oncogene homolog 4, ERBB4, HER4, human epidermal growth factor receptor 4, p180erbB4, Proto-oncogene-like protein c-ErbB-4

Gene Symbol: ERBB4

Poids moléculaire: 180 kDa (precursor), 80/120 kDa (cleaved)

ID gène: 2066

UniProt: Q15303

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway