Recombinant HMGB1 anticorps

N° du produit ABIN7828259

L’anticorps anti-HMGB1 Monoclonal Lapin est utilisé pour la détection de HMGB1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC, FACS et IP.

Aperçu rapide pour Recombinant HMGB1 anticorps (ABIN7828259)

Antigène: HMGB1 (High Mobility Group Box 1 (HMGB1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp HMGB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: A253

Détail du produit anti-HMGB1 anticorps

Fonction: Recombinant HMGB1 Monoclonal Antibody

Purification: Protein A purified

Immunogène: Recombinant human HMGB1 fragment

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:500-1:2000,IHC 1:200-1:1000,FCM 1:50-1:100,IP 1:25

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur HMGB1

Antigène: HMGB1 (High Mobility Group Box 1 (HMGB1))

Autre désignation: HMGB1

Sujet: SBP,HMGB,High Mobility Group Protein,High mobility group protein B,HMG,HMG-1,HMG1,HMG3,SBP-1,HMGB1,Amphoterin,High Mobility Group Protein 1,High mobility group protein B1,High mobility group protein 1 (HMG-1),High mobility group protein 1,high mobility group protein B1,high-mobility group box 1,HMG1,HMG-1,HMG1DKFZp686A04236,HMG3,HMGB1,SBP-1,Chromosomal protein,DKFZp686A04236,High mobility group 1,High mobility group box 1,high-mobility group (nonhistone chromosomal) protein 1,HMGB 1,nonhistone,NONHISTONE CHROMOSOMAL PROTEIN HMG1,SBP 1,Sulfoglucuronyl carbohydrate binding protein,Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 25 kDa

Observed MW: 25 kDa

UniProt: P09429

Pathways: Signalisation p53, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome