IL-1 beta anticorps

N° du produit ABIN7862996

Cet anticorps anti-IL-1 beta Monoclonal Souris (Clone IL1B-465) (ABIN7862996) détecte spécifiquement IL-1 beta dans IHC, ELISA et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour IL-1 beta anticorps (ABIN7862996)

Antigène: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-1 beta est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: IL1B-465

Détail du produit anti-IL-1 beta anticorps

Fonction: Interleukin-1beta (IL-1beta) Antibody

Specificité: Recognizes a protein of 17-31 kDa, identified as interleukin 1beta. It shows no cross-reaction with interleukin 1alpha. Epitopes of MAb IL1B/463 and IL1B/465 are different and provide a good pair for developing an ELISA. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human IL1B protein

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur IL-1 beta

Antigène: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Autre désignation: Interleukin-1beta

Sujet:

Catabolin, Hematopoietin 1 (H1), IFN beta inducing factor, IL-1 beta, IL1B, IL1F2, Interleukin 1 beta precursor, Interleukin-1 beta, LAF, Osteoclast activating factor (OAF), Preinterleukin 1 beta, Pro interleukin 1 beta

LPS stimulated human peripheral blood mononuclear cells. Human colon or liver tissue.

Poids moléculaire: 31kDa (proprotein), 17kDa (mature)

ID gène: 3553, 126256

UniProt: P01584

Pathways: Signalisation NF-kappaB, Interferon-gamma Pathway, Signalisation TLR, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints, Inflammasome