HDAC7 anticorps (pSer358) (Cy5.5)

N° du produit ABIN743008

Détail du produit anti-HDAC7 anticorps (Cy5.5)

Antigène: HDAC7 (Histone Deacetylase 7 (HDAC7))

Épitope: pSer358

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC7 est conjugé à/à la Cy5.5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Souris, Rat

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human HDAC7 around the phosphorylation site of Ser358

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur HDAC7

Antigène: HDAC7 (Histone Deacetylase 7 (HDAC7))

Autre désignation: HDAC7 (HDAC7 Produits)

Synonymes: anticorps HD7A, anticorps HDAC7A, anticorps 5830434K02Rik, anticorps HD7, anticorps HD7a, anticorps Hdac7a, anticorps mFLJ00062, anticorps hdac7a, anticorps K2K18.5, anticorps K2K18_5, anticorps histone deacetylase7, anticorps histone deacetylase 7, anticorps histone deacetylase7, anticorps HDAC7, anticorps Hdac7, anticorps hdac7, anticorps HDA7

Sujet:

Synonyms: HDAC7 phospho S358, HDAC7 phospho Ser358, p-HDAC7 Ser358, HD 7a, HD7a, HDAC 7, HDAC 7A, HDAC7, HDAC7A, Histone deacetylase 7, Histone deacetylase 7A, DKFZP586J0917, OTTHUMP00000202813, OTTHUMP00000202814, FLJ99588, HDAC7_HUMAN.

Background: HDAC7 is a member of the class II mammalian histone deacetylases, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription.

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development