TP53BP1 anticorps (AA 1239-1972)

N° du produit ABIN7870362

L’anticorps anti-TP53BP1 Polyclonal Lapin est utilisé pour la détection de TP53BP1 dans des échantillons de Humain. Il a été validé pour WB, ELISA, IF, FACS et IHC (p).

Aperçu rapide pour TP53BP1 anticorps (AA 1239-1972) (ABIN7870362)

Antigène: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TP53BP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TP53BP1 anticorps

Épitope: AA 1239-1972

Fonction: P53 binding protein 1 Antibody / 53BP1

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids H1239-H1972) was used as the immunogen for the p53 binding protein 1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the p53 binding protein 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the p53 binding protein 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TP53BP1

Antigène: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Autre désignation: P53 binding protein 1

Sujet: TP53BP1 (Tumor Protein p53-Binding Protein 1), also called 53BP1, is a protein that in humans is encoded by the TP53BP1 gene. Iwabuchi et al.(1998) mapped the TP53BP1 gene to 15q15-q21 by FISH. Iwabuchi et al.(1994) showed that TP53BP1 binds to the conformationally sensitive central domain of wildtype p53 but not to mutant p53 in vitro. Immunoblot analysis by Iwabuchi et al.(1998) showed that expression of TP53BP1 or TP53BP2 enhances the transactivation function of p53 and induces the expression of p21(CDKN1A). Wang et al.(2002) used small interfering RNA directed against TP53BP1 in mammalian cells to demonstrate that TP53BP1 is a key transducer of the DNA damage checkpoint signal. TP53BP1 was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation.

UniProt: Q12888

Pathways: Réparation de l'ADN