GZMB anticorps (AA 73-187)

N° du produit ABIN7876662

L’anticorps anti-GZMB Monoclonal Souris est utilisé pour la détection de GZMB dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour GZMB anticorps (AA 73-187) (ABIN7876662)

Antigène: GZMB (Granzyme B (GZMB))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GZMB est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GZMB-3056

Détail du produit anti-GZMB anticorps

Épitope: AA 73-187

Fonction: Granzyme B Antibody

Purification: Protein G affinity chromatography

Immunogène: A recombinant human partial protein (amino acids 73-187) was used as the immunogen for the Granzyme B antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Granzyme B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Granzyme B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur GZMB

Antigène: GZMB (Granzyme B (GZMB))

Autre désignation: Granzyme B

Sujet: Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease.

UniProt: P10144

Pathways: Apoptose, Caspase Cascade in Apoptosis