Recombinant GADD34 anticorps

N° du produit ABIN7938135

Cet anticorps anti-GADD34 Monoclonal Lapin (Clone 4K3) (ABIN7938135) détecte spécifiquement GADD34 dans WB. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour Recombinant GADD34 anticorps (ABIN7938135)

Antigène: GADD34 (PPP1R15A) (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp GADD34 est non-conjugé

Application: Western Blotting (WB)

Clone: 4K3

Détail du produit anti-GADD34 anticorps

Fonction: GADD34 antibody (rAb), 100 μl (Clone 4K3)

Purification: Protein A Chromatography

Immunogène: This antibody was raised against the GADD34 fusion protein.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:2000-1:16000 dilution

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur GADD34

Antigène: GADD34 (PPP1R15A) (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A))

Autre désignation: GADD34

Sujet:

Background_Plain: GADD34, also named PPP1R15A, belongs to the PPP1R15 family. GADD34 can be triggered as a direct target of activating transcription factor4 (ATF4) under ER stress, it plays a pivotal role in the recovery of cells from shut-down of translation induced by ER stress. It recruits the serine/threonine-protein phosphatase (PP1) to dephosphorylate the translation initiation factor eIF2alpha, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. GADD34 down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 via PP1. It may also promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Starvation-induced expression of GADD34 reduced mTOR activity and induced autophagy in wild-type mice, but not in GADD34 KO mice.

Aliases: Growth-arrest- and DNA-damage-induced transcript 34, PPP1R15A

Poids moléculaire: 73 kDa

Pathways: ER-Nucleus Signaling, Unfolded Protein Response