Integrin Alpha2b anticorps (AA 351-450)

N° du produit ABIN748358

L’anticorps Lapin Polyclonal anti-Integrin Alpha2b a été validé pour FACS, WB, ELISA, IHC (fro), IHC (p), IF (p) et IF (cc). Il convient pour détecter Integrin Alpha2b dans des échantillons de Humain et Rat. Il y a 4+ publications disponibles.

Aperçu rapide pour Integrin Alpha2b anticorps (AA 351-450) (ABIN748358)

Antigène: Integrin Alpha2b (CD41)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Integrin Alpha2b est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Détail du produit anti-Integrin Alpha2b anticorps

Épitope: AA 351-450

Réactivité croisée: Humain, Rat

Homologie: Mouse,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse Integrin alpha 2b

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Integrin Alpha2b (ABIN748358)

Sugiyama, Gamage, Zyla, Armstrong, Advani, Advani, Wang, Lee: "Influenza Virus Infection Induces Platelet-Endothelial Adhesion Which Contributes to Lung Injury." dans: Journal of virology, Vol. 90, Issue 4, pp. 1812-23, (2016) (PubMed).

Araki, Ogawara, Suzuki, Kawai, Watanabe, Ono, Higaki: "Augmented EPR effect by photo-triggered tumor vascular treatment improved therapeutic efficacy of liposomal paclitaxel in mice bearing tumors with low permeable vasculature." dans: Journal of controlled release : official journal of the Controlled Release Society, Vol. 200, pp. 106-14, (2015) (PubMed).

Lê, Schneider, Boergeling, Berri, Ducatez, Guerin, Adrian, Errazuriz-Cerda, Frasquilho, Antunes, Lina, Bordet, Jandrot-Perrus, Ludwig, Riteau: "Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis." dans: American journal of respiratory and critical care medicine, (2015) (PubMed).

Mei, Yin, Jin, He, Yin: "The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation." dans: Endocrinology, Vol. 154, Issue 12, pp. 4640-9, (2013) (PubMed).

Détails sur Integrin Alpha2b

Antigène: Integrin Alpha2b (CD41)

Autre désignation: Integrin alpha 2b/CD41

Sujet:

Synonyms: CD41, CD41B, GpIIb, AI172977, alphaIIb, Integrin alpha-IIb, GPalpha IIb, Platelet membrane glycoprotein IIb, Itga2b

Background: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

ID gène: 16399

UniProt: Q9QUM0

Pathways: Integrin Complex