SPHK1 anticorps (AA 1-100)

N° du produit ABIN748598

L’anticorps Lapin Polyclonal anti-SPHK1 a été validé pour WB, ELISA, FACS, IHC (p), IF (cc), IF (p) et IHC (fro). Il convient pour détecter SPHK1 dans des échantillons de Humain, Souris et Rat. Il y a 3+ publications disponibles.

Aperçu rapide pour SPHK1 anticorps (AA 1-100) (ABIN748598)

Antigène: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPHK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-SPHK1 anticorps

Épitope: AA 1-100

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SPHK1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-SPHK1 (ABIN748598)

Tran, Jersmann, Truong, Hamon, Roscioli, Ween, Pitman, Pitson, Hodge, Reynolds, Hodge: "Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD." dans: PLoS ONE, Vol. 12, Issue 11, pp. e0179577, (2017) (PubMed).

Tani, Tabuchi, Hara: "Hair Cell Loss Induced by Sphingosine and a Sphingosine Kinase Inhibitor in the Rat Cochlea." dans: Neurotoxicity research, Vol. 29, Issue 1, pp. 35-46, (2016) (PubMed).

Tran, Barnawi, Ween, Hamon, Roscioli, Hodge, Reynolds, Pitson, Davies, Haberberger, Hodge: "Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720." dans: Journal of leukocyte biology, Vol. 100, Issue 1, pp. 195-202, (2016) (PubMed).

Détails sur SPHK1

Antigène: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Autre désignation: SPHK1

Sujet:

Synonyms: SPHK, Sphingosine kinase 1, SK 1, SPK 1, SPHK1, SPK

Background: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.

ID gène: 8877

UniProt: Q9NYA1

Pathways: VEGF Signaling