ATF4 anticorps (pSer245)

N° du produit ABIN756172

Détail du produit anti-ATF4 anticorps

Antigène: ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))

Épitope: pSer245

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATF4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human ATF4 around the phosphorylation site of Ser245

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-ATF4 (ABIN756172)

Jiang, Yun, Shi, Niu, Gao, Xie, Yu: "Downregulation of miR-384-5p attenuates rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through inhibiting endoplasmic reticulum stress." dans: American journal of physiology. Cell physiology, Vol. 310, Issue 9, pp. C755-63, (2016) (PubMed).

Hayashi, Ouchi, Endou, Anzai: "HOXB9 acts as a negative regulator of activated human T cells in response to amino acid deficiency." dans: Immunology and cell biology, Vol. 94, Issue 6, pp. 612-7, (2016) (PubMed).

Détails sur ATF4

Antigène: ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))

Autre désignation: ATF4 (ATF4 Produits)

Synonymes: anticorps CREB-2, anticorps CREB2, anticorps TAXREB67, anticorps TXREB, anticorps ATF4, anticorps atf-4, anticorps creb-2, anticorps creb2, anticorps taxreb67, anticorps txreb, anticorps atf4, anticorps wu:fj01c08, anticorps wu:fk30b04, anticorps zgc:85951, anticorps sb:eu681, anticorps wu:fb08f07, anticorps zgc:171702, anticorps Atf-4, anticorps C/ATF, anticorps ATF4-I, anticorps atf4-a, anticorps atf4-b, anticorps atf4-ii, anticorps activating transcription factor 4, anticorps activating transcription factor 4 L homeolog, anticorps activating transcription factor 4a, anticorps activating transcription factor 4b, anticorps activating transcription factor 4 S homeolog, anticorps ATF4, anticorps atf4, anticorps Atf4, anticorps atf4.L, anticorps atf4a, anticorps atf4b, anticorps atf4.S

Sujet:

Synonyms: ATF4 phospho S245, ATF4Ser245, Cyclic AMP response element binding protein 2, DNA binding protein TAXREB67, Activating Transcription Factor 4, ATF 4, ATF4 protein, CREB 2, CREB2, CREB-2, Cyclic AMP dependent transcription factor ATF 4, Tax Responsive Enhancer Element B67, TAXREB67, TXREB.

Background: ATF4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain (referenced from Entrez gene).

ID gène: 468

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response