EGFR anticorps (pTyr1016) (Biotin)

N° du produit ABIN758124

Cet anticorps anti-EGFR est un anticorps Lapin Polyclonal détectant EGFR dans ELISA, IHC (p) et IHC (fro). Adapté pour Rat.

Aperçu rapide pour EGFR anticorps (pTyr1016) (Biotin) (ABIN758124)

Antigène: EGFR (Epidermal Growth Factor Receptor (EGFR))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EGFR est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-EGFR anticorps (Biotin)

Épitope: pTyr1016

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human EGFR around the phosphorylation site of Tyr1016

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur EGFR

Antigène: EGFR (Epidermal Growth Factor Receptor (EGFR))

Autre désignation: EGFR

Sujet:

Synonyms: EGFR, Avian erythroblastic leukemia viral v erb b oncogene homolog, Avian erythroblastic leukemia viral verbb oncogene homolog, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, EGF R, EGFR, Epidermal growth factor receptor avian erythroblastic leukemia viral v erb b oncogene homolog, Epidermal growth factor receptor erythroblastic leukemia viral v erb b oncogene homolog avian, Epidermal growth factor receptor, erbb 1, Erbb, Erbb1, HER1, mENA, Oncogene ERBB, PIG61, Receptor tyrosine protein kinase ErbB 1, Receptor tyrosine protein kinase ErbB1, Urogastrone, wa2, Wa5.

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.

ID gène: 1956

Pathways: Signalisation NF-kappaB, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins