RHOA anticorps (pSer188)

N° du produit ABIN758242

Cet anticorps Lapin Polyclonal détecte spécifiquement RHOA dans WB, ELISA, FACS, IHC (p), IF (cc), IF (p) et IHC (fro). Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 2+ publications.

Aperçu rapide pour RHOA anticorps (pSer188) (ABIN758242)

Antigène: RHOA (Ras Homolog Gene Family, Member A (RHOA))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RHOA est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-RHOA anticorps

Épitope: pSer188

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Sheep,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human RhoA around the phosphorylation site of Ser188

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-RHOA (ABIN758242)

Gu, Feng, Yu, Yuan, Yin, Ding, Zhao, Xu, Xu, Che: "Fasudil attenuates soluble fms-like tyrosine kinase-1 (sFlt-1)-induced hypertension in pregnant mice through RhoA/ROCK pathway." dans: Oncotarget, Vol. 8, Issue 61, pp. 104104-104112, (2017) (PubMed).

Zhang, He, Lu, Bian, Yang, Fu, Wu, Li: "HSF1 Relieves Amyloid-?-Induced Cardiomyocytes Apoptosis." dans: Cell biochemistry and biophysics, (2015) (PubMed).

Détails sur RHOA

Antigène: RHOA (Ras Homolog Gene Family, Member A (RHOA))

Autre désignation: RhoA

Sujet:

Synonyms: RHOAphospho S188, RhoA protein, Aplysia ras related homolog 12, ARH 12, ARH12, ARHA, H 12, Oncogene RHO H12, Ras homolog gene family member A, RHO 12, Rho A, RHO H12, RHO12, RHOH 12, RHOH12, Small GTP binding protein Rho A, Small GTP binding protein RhoA, Transforming protein Rho A, Transforming protein RhoA.

Background: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

ID gène: 387

Pathways: Dynamique des Microtubules, Signalisation WNT, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling, SARS-CoV-2 Protein Interactome