NLRP1 anticorps (Middle Region)

N° du produit ABIN8106572

L’anticorps anti-NLRP1 Polyclonal Lapin est utilisé pour la détection de NLRP1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour NLRP1 anticorps (Middle Region) (ABIN8106572)

Antigène: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NLRP1 anticorps

Épitope: Middle Region

Fonction: NLRP1 Antibody - middle region

Séquence: LCSLAAEGIW QKKTLFSPDD LRKHGLDGAI ISTFLKMGIL QEHPIPLSYS

Homologie: Cow: 85%, Dog: 100%, Horse: 79%, Human: 100%

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NLRP1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54479-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur NLRP1

Antigène: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Autre désignation: NLRP1

Sujet:

Background Information: This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Gene Name: NLR family pyrin domain containing 1

Alternative Symbols: NAC, JRRP, MSPC, AIADK, CARD7, CIDED, NALP1, SLEV1, DEFCAP, PP1044, VAMAS1, CLR17.1, DEFCAP-L/S

Protein Name: NACHT, LRR and PYD domains-containing protein 1

Poids moléculaire: 157 kDa

ID gène: 22861

NCBI Accession: NP_001028225

UniProt: Q9C000

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome