PRMT6 anticorps (AA 301-375)

N° du produit ABIN761876

Détail du produit anti-PRMT6 anticorps

Antigène: PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))

Épitope: AA 301-375

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRMT6 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PRMT6

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur PRMT6

Antigène: PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))

Autre désignation: Prmt6 (PRMT6 Produits)

Synonymes: anticorps CG9927, anticorps DART6, anticorps Dmel\\CG9927, anticorps PRMT6, anticorps HRMT1L6, anticorps ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 6, anticorps ATPRMT6, anticorps protein arginine methyltransferase 6, anticorps DKFZp459B1431, anticorps Hrmt1l6, anticorps hrmt1l6, anticorps hrmt6, anticorps im:6908706, anticorps AW124876, anticorps BB233495, anticorps Arginine methyltransferase 6, anticorps protein arginine methyltransferase 6, anticorps protein arginine methyltransferase 6 S homeolog, anticorps arginine N-methyltransferase, type I, anticorps protein arginine N-methyltransferase 6, anticorps Art6, anticorps PRMT6, anticorps prmt6.S, anticorps prmt6, anticorps Prmt6

Sujet:

Synonyms: HRMT1L6, Protein arginine N-methyltransferase 6, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6, PRMT6

Background: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).

ID gène: 55170

UniProt: Q96LA8