MAP3K7 anticorps (Internal Region)

N° du produit ABIN784213

Cet anticorps Lapin Polyclonal détecte spécifiquement MAP3K7 dans WB, IHC (p) et EIA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour MAP3K7 anticorps (Internal Region) (ABIN784213)

Antigène: MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP3K7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-MAP3K7 anticorps

Épitope: Internal Region

Specificité: This antibody detects endogenous levels of total MAP3K7 protein.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogène: Synthetic peptide - KLH conjugated Remarks: Antigen Modification: Internal

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02 % Sodium Azide and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur MAP3K7

Antigène: MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Autre désignation: TAK1 / MAP3K7

Sujet: MEKK7, known as TAK1 for transforming growth factor (TGF) beta-activated kinase-1, is a MLK (MAP3K) type protein kinase which is associated with several signaling pathways. The protein contains a N-terminal protein kinase domain preceeded by a short regulatory motif and followed by a C-terminal extension of unknown function. TAK1 is activated by TGF beta and tumor necrosis factor (TNF). Further, TAK1 binding proteins, TAB-1 and -2, bind to the N-terminal regulatory motif and couple TAK1 to additional upstream signals, including the human X chromosome-linked inhibitor of apoptosis. TAK1 regulates the JNK cascade by phosphorylating MKK4/MAP2K4 and p38 cascades by phosphorylating MEK3/MAP2K3 and MKK6/MAP2K6. TAK1 also has been implicated in interleukin-1 (IL-1) signaling to JNKs via direct activation by IL-1 or by forming a complex with TRAF6, TAB1 and TAB2. At least four protein isoforms, resulting from alternatively spliced transcript variants, have been identified - 491, 518, 579 and 606 amino acids.Synonyms: Mitogen-activated protein kinase kinase kinase 7, TAK-1, TAK1, TGF-beta-activated kinase 1, Transforming growth factor-beta-activated kinase 1

ID gène: 6885

NCBI Accession: NP_003179

Pathways: Signalisation NF-kappaB, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway