MAP3K7 anticorps (Internal Region)

N° du produit ABIN784213

Détail du produit anti-MAP3K7 anticorps

Antigène: MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP3K7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects endogenous levels of total MAP3K7 protein.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogène: Synthetic peptide - KLH conjugated Remarks: Antigen Modification: Internal

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02 % Sodium Azide and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur MAP3K7

Antigène: MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Autre désignation: TAK1 / MAP3K7 (MAP3K7 Produits)

Synonymes: anticorps si:ch211-225h9.1, anticorps zgc:110612, anticorps Tak1, anticorps MEKK7, anticorps TAK1, anticorps TGF1a, anticorps B430101B05, anticorps C87327, anticorps mitogen-activated protein kinase kinase kinase 7, anticorps mitogen activated protein kinase kinase kinase 7, anticorps map3k7, anticorps Map3k7, anticorps MAP3K7

Sujet: MEKK7, known as TAK1 for transforming growth factor (TGF) beta-activated kinase-1, is a MLK (MAP3K) type protein kinase which is associated with several signaling pathways. The protein contains a N-terminal protein kinase domain preceeded by a short regulatory motif and followed by a C-terminal extension of unknown function. TAK1 is activated by TGF beta and tumor necrosis factor (TNF). Further, TAK1 binding proteins, TAB-1 and -2, bind to the N-terminal regulatory motif and couple TAK1 to additional upstream signals, including the human X chromosome-linked inhibitor of apoptosis. TAK1 regulates the JNK cascade by phosphorylating MKK4/MAP2K4 and p38 cascades by phosphorylating MEK3/MAP2K3 and MKK6/MAP2K6. TAK1 also has been implicated in interleukin-1 (IL-1) signaling to JNKs via direct activation by IL-1 or by forming a complex with TRAF6, TAB1 and TAB2. At least four protein isoforms, resulting from alternatively spliced transcript variants, have been identified - 491, 518, 579 and 606 amino acids.Synonyms: Mitogen-activated protein kinase kinase kinase 7, TAK-1, TAK1, TGF-beta-activated kinase 1, Transforming growth factor-beta-activated kinase 1

ID gène: 6885

NCBI Accession: NP_003179

Pathways: Signalisation NF-kappaB, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway