Osteoprotegerin anticorps

N° du produit ABIN784548

Détail du produit anti-Osteoprotegerin anticorps

Antigène: Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Osteoprotegerin est non-conjugé

Application: Enzyme Immunoassay (EIA)

Specificité: Recognizes Human Osteoprotegerin. Other species not tested.

Purification: Affinity Chromatography

Immunogène: Purified recombinant Human Osteoprotegerin Genename: TNFRSF11B

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in aqua bidest to 1 mg/mL

Buffer: PBS, pH 7.4

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store lyophilized at 2-8 °C and reconstituted at -20 °C.

Détails sur Osteoprotegerin

Antigène: Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))

Autre désignation: Osteoprotegerin / TNFRSF11B (TNFRSF11B Produits)

Synonymes: anticorps CD254, anticorps ODF, anticorps OPGL, anticorps OPTB2, anticorps RANKL, anticorps TRANCE, anticorps hRANKL2, anticorps sOdf, anticorps OCIF, anticorps OPG, anticorps TR1, anticorps Opg, anticorps ocif, anticorps opg, anticorps tr1, anticorps TNF superfamily member 11, anticorps TNF receptor superfamily member 11b, anticorps tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin), anticorps TNF receptor superfamily member 11B, anticorps tumor necrosis factor receptor superfamily member 11b S homeolog, anticorps tumor necrosis factor receptor superfamily, member 11b, anticorps TNFSF11, anticorps TNFRSF11B, anticorps Tnfrsf11b, anticorps tnfrsf11b.S

Classe de substances: Chemical

Sujet: Bone morphogenesis and remodeling involve the formation of bone from osteoblasts and the resorption of bone by osteoclasts. The cytokine osteoprotegerin (OPG), also designated Osteoclastogenesis Inhibitory Factor (OCIF), is known to inhibit osteoclast formation. A secreted glycoprotein, OPG is a member of the TNF receptor family that increases bone density and volume. OPG is thought to inhibit osteoclastogenesis by disrupting the cell-to-cell signaling between osteoblastic stromal cells and osteoclast progenitors. OPG is known to bind to TRAIL, a death domain-containing protein, and to inhibit TRAIL apoptosis in Jurkat cells. OPG also binds to osteoclast differentiation factor (ODF), also known as TRANCE/RANKL, a membrane-bound protein belonging to the TNF ligand family. Both TNFα and TNFβ upregulate OPG expression, while the bone resorbing agent prostaglandin E2 downregulates OPG.Synonyms: OCIF, OPG, Osteoclastogenesis inhibitory factor, Tumor necrosis factor receptor superfamily member 11B

ID gène: 4982

NCBI Accession: NP_002537