DAB1 anticorps (pSer524) (Alexa Fluor 488)
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- Antigène Voir toutes DAB1 Anticorps
- DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))
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Épitope
- pSer524
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DAB1 est conjugé à/à la Alexa Fluor 488
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris
- Homologie
- Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic phosphopeptide derived from mouse Dab1 around the phosphorylation site of Ser524
- Isotype
- IgG
- Top Product
- Discover our top product DAB1 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))
- Autre désignation
- Dab1 (DAB1 Produits)
- Synonymes
- anticorps AI956902, anticorps C630028C02Rik, anticorps scm, anticorps scr, anticorps scrambler, anticorps yot, anticorps disabled-1, anticorps LOC100232823, anticorps si:dkey-242m13.1, anticorps DAB1, anticorps zgc:136547, anticorps DAB1, reelin adaptor protein, anticorps disabled 1, anticorps disabled homolog 1, anticorps Dab, reelin signal transducer, homolog 1a (Drosophila), anticorps Dab, reelin signal transducer, homolog 1b (Drosophila), anticorps DAB1, anticorps Dab1, anticorps LOC100232823, anticorps dab1a, anticorps dab1b
- Sujet
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Synonyms: Dab 1, Disabled homolog 1, Disabled homolog 1 Drosophila, Scm, Scr, Scrambler, Yot, Yotari.
Background: Disabled 1 (Dab1) is an 80 kDa protein that is encoded by the Disabled-1 gene locus which is mutated in scrambler and yotari mutant mice. Phenotypically, the mutation of this gene produces motor defects and ataxia, disruption of neuronal migration, and severe cerebellar hypoplasia. Dab1 is an intracellular adapter protein that functions in downstream signaling events initiated by the secreted protein reelin. Dab1 contains a phosphotyrosine binding (PTB) domain in the amino terminus. Tyrosine phosphorylation of Dab1 is increased by reelin binding to the Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) through stimulation of Src family kinases. Src family kinase and c-Abl activities are themselves then stimulated by binding to tyrosine phosphorylated Dab1. Dab1 also mediates activation of Akt (PKB) by reelin resulting in inhibition of glycogen synthase kinase 3 beta (GSK-3 beta) and decreased phosphorylation of the microtubule-associated protein, Tau. Dab1 serine 491 is phosphorylated in a Cdk5-dependent manner and regulates, likely indirectly, Reelin-induced signaling during neural cortex development.
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