PPP1R12A anticorps (pSer507) (AbBy Fluor® 350)
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- Antigène Voir toutes PPP1R12A Anticorps
- PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
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Épitope
- pSer507
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Reactivité
- Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PPP1R12A est conjugé à/à la AbBy Fluor® 350
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Souris
- Homologie
- Human,Rat,Dog,Cow,Horse,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic phosphopeptide derived from human MYPT1 around the phosphorylation site of Ser507
- Isotype
- IgG
- Top Product
- Discover our top product PPP1R12A Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
- Autre désignation
- MYPT1 (PPP1R12A Produits)
- Synonymes
- anticorps 1200015F06Rik, anticorps 5730577I22Rik, anticorps AA792106, anticorps AV099298, anticorps D10Ertd625e, anticorps Mypt1, anticorps M130, anticorps MBS, anticorps MYPT1, anticorps M110, anticorps MBSP, anticorps protein phosphatase 1, regulatory (inhibitor) subunit 12A, anticorps protein phosphatase 1 regulatory subunit 12A, anticorps protein phosphatase 1, regulatory subunit 12A, anticorps Ppp1r12a, anticorps PPP1R12A
- Sujet
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Synonyms: Myosin Phosphatase phospho Ser507, p-MBSSer507, Myosin Phosphatase phospho S507, p-MYPT1Ser507, Myosin Phosphatase, M130, MBS, MGC133042, Myosin phosphatase target subunit 1, Myosin phosphatase targeting subunit 1, MYPT 1, MYPT1, PPP1R12A, Protein phosphatase 1 regulatory inhibitor subunit 12A, Protein phosphatase 1 regulatory subunit 12A, Protein phosphatase myosin binding subunit, MYPT1_HUMAN, Myosin phosphatase-targeting subunit 1, Protein phosphatase myosin-binding subunit.
Background: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate(GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
- ID gène
- 4659
- Pathways
- M Phase
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