Cathelicidin anticorps (AA 101-170) (Alexa Fluor 647)

N° du produit ABIN886752

Détail du produit anti-Cathelicidin anticorps (Alexa Fluor 647)

Antigène: Cathelicidin (CAMP) (Cathelicidin Antimicrobial Peptide (CAMP))

Épitope: AA 101-170

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cathelicidin est conjugé à/à la Alexa Fluor 647

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Calicidin

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Cathelicidin

Antigène: Cathelicidin (CAMP) (Cathelicidin Antimicrobial Peptide (CAMP))

Autre désignation: Cathelicidin (CAMP Produits)

Synonymes: anticorps CAP-18, anticorps CAP18, anticorps CRAMP, anticorps FALL-39, anticorps FALL39, anticorps LL37, anticorps CATH-2, anticorps Cnlp, anticorps Cramp, anticorps MCLP, anticorps CATH-B1, anticorps CATHB1, anticorps CATHL2, anticorps CATHL7, anticorps CAP11, anticorps cathelicidin antimicrobial peptide, anticorps CAMP, anticorps LOC100136187, anticorps LOC100136439, anticorps Camp

Sujet:

Synonyms: 18 kDa cationic antimicrobial protein; Antibacterial protein FALL-39; Antibacterial protein LL-37; CAMP; CAMP_HUMAN; CAP 18; CAP-18; CAP18; cathelicidin antimicrobial peptide; Cathelicidin antimicrobial peptide precursor; Cathelin-like protein; Cathelin-related antimicrobial peptide; CATHL3; Cationic antimicrobial protein CAP 18; Cationic antimicrobial protein, 18-KD; CLP; Cnlp; Cramp; CRAMP, mouse, homolog of; FALL 39; FALL 39 peptide antibiotic; FALL-39 peptide antibiotic; FALL39; hCAP 18; hCAP-18; hCAP18; HSD26; LL 37; LL37; MCLP; mcramp; Peptide antibiotic, PR-39, porcine, homolog of; SOB3.

Background: Cathelicidins are a family of antimicrobial proteins found in the peroxidase-negative granules of neutrophils. Along with the family of proteins known as defensins, cathelicidins participate in the first line of defense by preventing local infection and systemic invasion of microbes. FALL-39 precursor (FALL-39 peptide antibiotic, cationic anti-microbial protein, CAMP, CAP-18, HSD26) is a cathelicidin anti-microbial protein that contains the antibacterial peptide LL-37 (amino acids 134-170). In contrast to the defensins, which are cysteine-rich peptides that fold in -pleated sheets, LL-37 is a cysteine-free peptide that can adopt an amphipathic å-helical conformation. LL-37 binds to bacterial lipopolysaccharides (LPS) and is a potent chemotactic factor for recruiting mast cells to sites of inflammation. LL-37 is present in inflammatory skin diseases that include psoriasis, sub-acute lupus erthematosus, dermatitis and nickel contact hypersensitivity. It is not found in normal skin epidermis. The secreted protein is expressed primarily in bone marrow, testis and neutrophils. The mouse and rat ortholog, CRAMP (cathelin-related antimicrobial peptide), is also part of the cathelicidin family of host defense peptides. These include precursors of potent antimicrobial peptides that direct antimicrobial activity against various microbial pathogens and also activate mesenchymal cells during wound repair. CRAMP is expressed in testis, spleen, stomach and intestine.

ID gène: 820

Pathways: Cellular Response to Molecule of Bacterial Origin