HDAC6 anticorps (AA 301-400) (Alexa Fluor 647)
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- Antigène Voir toutes HDAC6 Anticorps
- HDAC6 (Histone Deacetylase 6 (HDAC6))
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Épitope
- AA 301-400
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HDAC6 est conjugé à/à la Alexa Fluor 647
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Rat
- Homologie
- Mouse,Cow,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human HDAC6
- Isotype
- IgG
- Top Product
- Discover our top product HDAC6 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- HDAC6 (Histone Deacetylase 6 (HDAC6))
- Autre désignation
- HDAC6 (HDAC6 Produits)
- Synonymes
- anticorps HD6, anticorps Hd6, anticorps Hdac5, anticorps Sfc6, anticorps mHDA2, anticorps CG6170, anticorps DHDAC2, anticorps DmHDAC2, anticorps Dmel\\CG6170, anticorps HDAC, anticorps HDAC2, anticorps dHDAC2, anticorps dHDAC6, anticorps dmHDA404, anticorps hdac6, anticorps MGC53140, anticorps wu:fc31d02, anticorps dsim_GLEANR_17355, anticorps DsimGD17207, anticorps GD17207, anticorps HDAC6, anticorps ATHDA6, anticorps AXE1, anticorps HISTONE DEACETYLASE 6, anticorps MDC12.7, anticorps MDC12_7, anticorps RNA-MEDIATED TRANSCRIPTIONAL SILENCING 1, anticorps RPD3B, anticorps RTS1, anticorps SIL1, anticorps histone deacetylase 6, anticorps histone deacetylase 6, anticorps Histone deacetylase 6, anticorps histone deacetylase 6 L homeolog, anticorps GD17207 gene product from transcript GD17207-RB, anticorps Histone DeAcetylase, anticorps HDAC6, anticorps Hdac6, anticorps hdac6.L, anticorps hdac6, anticorps Dsim\HDAC6, anticorps PTRG_03035, anticorps HDA6, anticorps hda-6
- Sujet
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Synonyms: HD6, JM21, CPBHM, PPP1R90, Histone deacetylase 6, HDAC6, KIAA0901
Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
- ID gène
- 10013
- UniProt
- Q9UBN7
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
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