Humain Papilloma Virus 33 E7 (HPV-33 E7) (AA 41-97) anticorps (Alexa Fluor 488)

N° du produit ABIN901252

Détail du produit

Antigène: Human Papilloma Virus 33 E7 (HPV-33 E7)

Épitope: AA 41-97

Reactivité: Humain, Human Papillomavirus (HPV), Virus

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Alexa Fluor 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Specificité: This antibody will also detect E7 in HPV58, but with slightly less affinity, due to a one amino acid change in the immunogen sequence range.

Réactivité croisée: Humain, Virus

Réactivité croisée (Details): HPV33

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from HPV33 E7

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Human Papilloma Virus 33 E7 (HPV-33 E7)

Autre désignation: HPV33 E7

Classe de substances: Viral Protein

Sujet:

Synonyms: E7 protein [Human papillomavirus type 33], Human Papilloma Virus, Human papillomavirus type 33, Human papillomavirus type 33, Protein 33, early protein E7 [Human papillomavirus type 33].

Background: E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).