SERPINB2 anticorps (AA 131-230) (Alexa Fluor 647)
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- Antigène Voir toutes SERPINB2 Anticorps
- SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))
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Épitope
- AA 131-230
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SERPINB2 est conjugé à/à la Alexa Fluor 647
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Dog,Cow,Pig,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human PAI-2
- Isotype
- IgG
- Top Product
- Discover our top product SERPINB2 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))
- Autre désignation
- Pai-2/Serpinb2 (SERPINB2 Produits)
- Synonymes
- anticorps HsT1201, anticorps PAI, anticorps PAI-2, anticorps PAI2, anticorps PLANH2, anticorps SERPINB2, anticorps Planh2, anticorps ovalbumin, anticorps Pai2a, anticorps serpin family B member 2, anticorps serpin peptidase inhibitor, clade B (ovalbumin), member 2, anticorps serine (or cysteine) peptidase inhibitor, clade B, member 2, anticorps SERPINB2, anticorps Serpinb2
- Classe de substances
- Amino Acid
- Sujet
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Synonyms: Serpin B2, Serpinb2, SerpinB2, plasminogen activator inhibitor 2, HsT1201, Monocyte Arg serpin, Monocyte Arg-serpin, PAI2A, PAI, PAI-2, PAI 2, PAI2, Placental plasminogen activator inhibitor, PAI2_RAT, PLANH2, Plasminogen activator inhibitor 2, Plasminogen activator inhibitor 2 type A, Serpin peptidase inhibitor clade B ovalbumin member 2, Urokinase inhibitor.
Background: SerpinB2 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in the placenta, and given the name PAI-2 because of the ability to inhibit urokinase plasminogen activator (u-PA) at low micromolar efficiency. SerpinB2 also inhibits tissue plasminogen activator (t-PA), but with micromolar efficiency, and PAI-1 is much more efficient that SerpinB2 on both forms of plasminogen activator. The structure of PAI-2 is not terribly similar to PAI-1, however, which is an E clade serpin. SerpinB2 is made by many cell types, and is found intracellularly as an unglycosylated kDa protein, and secreted as a 60 kDa protein. SerpinB2 is found in saliva, secreted by gingival fibroblasts, and in the skin. SerpinB2 levels are elevated in serum during pregnancy, and in leukemia, breast cancer and ovarian cancer, although it was lowered in some cancers.A shorter SerpinB2 isoform of 382 amino acids, has been reported, with a predicted mass of 43.1 kDa and a pI of 5.69. The shorter form has a deletion just after the start of the mature protein, but it is unclear what the relative production and distribution is for the shorter sequence.
- ID gène
- 5055
- Pathways
- Autophagy
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