5HT1B Receptor anticorps (N-Term)

N° du produit ABIN926037

Cet anticorps anti-5HT1B Receptor est un anticorps Lapin Polyclonal détectant 5HT1B Receptor dans WB. Adapté pour Humain.

Aperçu rapide pour 5HT1B Receptor anticorps (N-Term) (ABIN926037)

Antigène: 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp 5HT1B Receptor est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-5HT1B Receptor anticorps

Épitope: N-Term

Immunogène: HTR1 B antibody was raised in rabbit using the N terminal of HTR1 as the immunogen

Information d'application

Indications d'application: WB: 1.25 µg/mL
Optimal conditions should be determined by the investigator.

Commentaires:

HTR1B Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this HTR1B antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur 5HT1B Receptor

Antigène: 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))

Autre désignation: HTR1B

Sujet: The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant. Synonyms: Polyclonal HTR1B antibody, Anti-HTR1B antibody, 5-hydroxytryptamine, serotonin receptor 1B antibody.

Pathways: Signalistation JAK/STAT, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, S100 Proteins