MLL/KMT2A anticorps (AA 3751-3968)

N° du produit ABIN931441

Détail du produit anti-MLL/KMT2A anticorps

Antigène: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Épitope: AA 3751-3968

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MLL/KMT2A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogène: MLL antibody was raised in Mouse using a purified recombinant fragment of MLL(aa3751-3968) expressed in E. coli as the immunogen.

Clone: 10F8D7

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as a liquid in ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term storage. Store at -20 °C for long term storage.

Détails sur MLL/KMT2A

Antigène: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Autre désignation: MLL (MLL Produits)

Synonymes: anticorps ALL-1, anticorps CXXC7, anticorps HRX, anticorps HTRX1, anticorps MLL, anticorps MLL/GAS7, anticorps MLL1A, anticorps TET1-MLL, anticorps TRX1, anticorps WDSTS, anticorps 6430520K01, anticorps All1, anticorps Cxxc7, anticorps Mll, anticorps Mll1, anticorps mKIAA4050, anticorps lysine methyltransferase 2A, anticorps lysine (K)-specific methyltransferase 2A, anticorps KMT2A, anticorps Kmt2a

Sujet: MLL contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Synonyms: Monoclonal MLL antibody, Anti-MLL antibody, Myeloid/lymphoid leukemia antibody, ALL-1 antibody, ALL 1 antibody, HRX antibody, Lysine N-methyltransferase 2A antibody, Trithorax-like protein antibody, Zinc finger protein HRX antibody.

Pathways: L'effet Warburg