Macrophage Mannose Receptor 1 anticorps (N-Term)

N° du produit ABIN953496

Détail du produit anti-Macrophage Mannose Receptor 1 anticorps

Antigène: Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))

Épitope: AA 358-388, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Macrophage Mannose Receptor 1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody recognizes CD 206 / MRC1 at N-term.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse

Purification: Purified through a Protein A column followed by peptide affinity purification

Immunogène: Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 358-388aa) of human CD206 / MRC1.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Macrophage Mannose Receptor 1

Antigène: Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))

Autre désignation: CD206 / MRC1 (MRC1 Produits)

Synonymes: anticorps CD206, anticorps CLEC13D, anticorps CLEC13DL, anticorps MMR, anticorps MRC1L1, anticorps bA541I19.1, anticorps AW259686, anticorps MR, anticorps mrc1, anticorps MGC86525, anticorps MRC1, anticorps MRC1L-A, anticorps mannose receptor C-type 1, anticorps mannose receptor, C type 1, anticorps mannose receptor C-type 1 L homeolog, anticorps mediator of replication checkpoint 1, anticorps MRC1, anticorps Mrc1, anticorps mrc1.L, anticorps mrc1

Sujet: CD206 is a transmembrane protein and member of the multilectin family of pattern recognition receptors (PRRs), which mediates phagocytosis and endocytosis, and is modulated by a range of factors including cytokines, immunoglobulin receptors and pathogens. CD206 has two extracellular lectin binding sites: the cysteine-rich domain binds to sulphated sugars of glycoproteins such as thyroid stimulating hormone, whilst the recognition of mannose and fucose occurs through carbohydrate recognition domains (CRDs). The widespread distribution and recognition of a wide range of antigens by macrophages, plays a key role in both innate and adaptive immunity, with CD206 able to bind to both gram-negative and gram-positive bacteria, mycobacterium, yeasts, fungi and parasites. The expression of CD206 is not restricted to macrophages, but is also present on immature dendritic cells (DCs), endothelial cells, kidney mesangial cells, retinal pigment epithelium and tracheal smooth muscle cells.Synonyms: C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, CLEC13D, CLEC13DL, MRC1L1, Macrophage mannose receptor, Macrophage mannose receptor 1-like protein 1

ID gène: 414308

NCBI Accession: NP_001009567