Importin 8 anticorps (C-Term)

N° du produit ABIN954450

Détail du produit anti-Importin 8 anticorps

Antigène: Importin 8 (IPO8)

Épitope: C-Term

Reactivité: Humain, Chien, Boeuf (Vache), Porc

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Importin 8 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Séquence: C-SAFNFGTVPS NN

Specificité: This antibody is expected to recognise isoform 1 (NP_006381.2) and isoform 2 (NP_001177924.1).

Réactivité croisée (Details): Species reactivity (expected):Dog, Pig, Cow.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the C-Terminus of the protein sequence according to NP_006381.2, NP_001177924.1. Genename: IPO8

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Importin 8

Antigène: Importin 8 (IPO8)

Autre désignation: RanBP8 / Importin-8 (IPO8 Produits)

Synonymes: anticorps IPO8, anticorps si:ch211-116i17.1, anticorps RANBP8, anticorps 6230418K12Rik, anticorps Abcc10, anticorps C130009K11Rik, anticorps MRP7, anticorps OM-1, anticorps Om1, anticorps Ranbp8, anticorps importin 8, anticorps IPO8, anticorps ipo8, anticorps Ipo8

Sujet: Importin 8 is a 1037 amino acid nuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.Synonyms: IMP8, IPO8, RAN binding protein 8

ID gène: 10526

NCBI Accession: NP_006381