SLC6A3 anticorps (Internal Region)

N° du produit ABIN954827

Détail du produit anti-SLC6A3 anticorps

Antigène: SLC6A3 (Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3))

Épitope: Internal Region

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC6A3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: C-QLTSSTLTNP RQSP

Specificité: Recognizes SLC6A3 / DAT

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the internal region (near N Terminus) of the protein sequence according to NP_001035.1. Genename: SLC6A3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-SLC6A3 (ABIN954827)

Wiers, Lohoff, Lee, Muench, Freeman, Zehra, Marenco, Lipska, Auluck, Feng, Sun, Goldman, Swanson, Wang, Volkow: "Methylation of the dopamine transporter gene in blood is associated with striatal dopamine transporter availability in ADHD: A preliminary study." dans: The European journal of neuroscience, Vol. 48, Issue 3, pp. 1884-1895, (2018) (PubMed).

Détails sur SLC6A3

Antigène: SLC6A3 (Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3))

Autre désignation: SLC6A3 / DAT (SLC6A3 Produits)

Synonymes: anticorps DAT, anticorps SLC6A3, anticorps Dat1, anticorps DAT1, anticorps PKDYS, anticorps solute carrier family 6 member 3, anticorps solute carrier family 6 (neurotransmitter transporter), member 3, anticorps Sodium-dependent dopamine transporter, anticorps solute carrier family 6 (neurotransmitter transporter, dopamine), member 3, anticorps SLC6A3, anticorps slc6a3, anticorps dat-1, anticorps Slc6a3

Sujet: Plasmalemmal neurotransmitter transporters sequester synaptic and peri synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, and it is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's disease, schizophrenia, and addiction. It is a 12 transmembrane domain transporter with the N and C terminal regions located within the cytoplasm.Synonyms: DA transporter, DAT1, Sodium-dependent dopamine transporter, Solute carrier family 6 member 3

ID gène: 6531

NCBI Accession: NP_001035

Pathways: Dopaminergic Neurogenesis