anticorps 1700011K09Rik, anticorps 4833424I06Rik, anticorps 4933429L05Rik, anticorps AI644424, anticorps StAR related lipid transfer domain containing 6, anticorps StAR-related lipid transfer (START) domain containing 6, anticorps STARD6, anticorps Stard6
Sujet
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1, MIM 184756) and by liver X receptors (e.g., LXRA, MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR, MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002 [PubMed 12011452])Synonyms: START domain-containing protein 6, StAR-related lipid transfer protein 6