USP7 anticorps (Middle Region)

N° du produit ABIN955493

L’anticorps anti-USP7 Polyclonal Lapin est utilisé pour la détection de USP7 dans des échantillons de Humain. Il a été validé pour WB et EIA.

Aperçu rapide pour USP7 anticorps (Middle Region) (ABIN955493)

Antigène: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP7 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-USP7 anticorps

Épitope: AA 319-348, Middle Region

Specificité: This antibody detects USP7 / HAUSP (Center).

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein A column followed by peptide affinity purification

Immunogène: KLH conjugated synthetic peptide between 319-348 amino acids from the Central region of human USP7

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Détails sur USP7

Antigène: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Autre désignation: USP7 / HAUSP

Sujet: Hydrolase that deubiquitinates target proteins such as FOXO4, TP53, MDM2, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and proteasomal degradation. Deubiquitinates TP53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.Synonyms: Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7

ID gène: 7874

NCBI Accession: NP_003461