ANKH anticorps (C-Term)

N° du produit ABIN965553

Détail du produit anti-ANKH anticorps

Antigène: ANKH (Ankylosis, Progressive Homolog (Mouse) (ANKH))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ANKH est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ANKH(Progressive ankylosis protein homolog)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-ANKH (ABIN965553)

Williams: "Familial calcium pyrophosphate dihydrate deposition disease and the ANKH gene." dans: Current opinion in rheumatology, Vol. 15, Issue 3, pp. 326-31, (2003) (PubMed).

Nelson, Clegg, Arnold, Ferguson, Bonham, White, Hood, Lin: "The program of androgen-responsive genes in neoplastic prostate epithelium." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 18, pp. 11890-5, (2002) (PubMed).

Williams, Zhang, Timms, Bonavita, Caeiro, Broxholme, Cuthbertson, Jones, Marchegiani, Reginato, Russell, Wordsworth, Carr, Brown: "Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH." dans: American journal of human genetics, Vol. 71, Issue 4, pp. 985-91, (2002) (PubMed).

Détails sur ANKH

Antigène: ANKH (Ankylosis, Progressive Homolog (Mouse) (ANKH))

Autre désignation: ANKH (ANKH Produits)

Synonymes: anticorps ANK, anticorps CCAL2, anticorps CMDJ, anticorps CPPDD, anticorps HANK, anticorps MANK, anticorps Ank, anticorps Ankh, anticorps D15Ertd221e, anticorps ank, anticorps mKIAA1581, anticorps ankh, anticorps wu:fc08d03, anticorps wu:fj64g09, anticorps zgc:110290, anticorps ANKH inorganic pyrophosphate transport regulator, anticorps progressive ankylosis, anticorps ANKH inorganic pyrophosphate transport regulator b, anticorps ANKH inorganic pyrophosphate transport regulator S homeolog, anticorps ANKH inorganic pyrophosphate transport regulator a, anticorps ANKH, anticorps Ankh, anticorps Ank, anticorps ankhb, anticorps ankh.S, anticorps ankha

Sujet: The ANKH (progressive ankylosis protein homolog) is a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. The ANKHOR and ANKH-TR are novel genetic markers that are significantly associated with ankylosing spondylitis. Mutation at the mouse `progressive ankylosis' (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. The human homolog is virtually identical to the mouse protein and ANKH-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.